Direct Answer
PCB stack-up defines the copper layers, dielectric layers, ground planes, power planes, and material system. High-speed boards need stack-up review because impedance and EMI behavior depend on geometry and material values.
Manufacturing Impact
Changing prepreg thickness, copper weight, or dielectric constant changes impedance. Hardware teams should align stack-up before routing USB, Ethernet, HDMI, DDR, RF, or other controlled-impedance nets.
For the layer-count decision behind the stack-up, compare 2 Layer vs 4 Layer PCB Stackup before freezing routing density, plane strategy, and impedance assumptions.
